There's a general comfort and ease that comes with photographing someone in their own room. Even if the subject is aware of you taking photos of them, the lack of others present and the familiarity of the environment still allows them to be slightly relaxed in front of the camera. See below for some quick shots of my friend Natalie in her bedroom. All were shot with a Canon 5d mark iii and post processed in lightroom.
These last three were taken while walking to dinner and in the bathroom at the restaurant.